POS0162 PREDICTIVE FACTORS OF A NEW FRAGILITY FRACTURE AFTER WRIST FRAGILITY FRACTURE

Background: Fragility fractures (FF) are that result from mechanical forces would not ordinarily in fracture, known as low-level (or ‘low energy’) trauma. 1 Studies have shown history of wrist fracture increases the risk for subsequent FF. 2 Objectives: To assess predictive factors FF occurring after a fracture. Methods: Retrospective monocentric study included patients with observed at emergency department (ED) tertiary center, between st January 2017 and 31 December 2018. Wrist were identified through 10th International Classification Diseases revision clinical record. Patients relevant missing data excluded. Seven hundred thirty-three identified. After calculating representative sample (90% confidence interval), 188 included. Their records until 31th 2020 (2 to 3 years FF) reviewed. SPSS was used statistical analysis significance level defined 2-sided p<0.05. In multivariate we variables significant association univariate those relevance (reported others studies). Results: represented 44.3% ED. Most woman (83.5%) mean age 70.7 (SD=11.2) years-old time their A previous seen 22.9% 13.3% had new during follow-up period. We found an occurrence number comorbidities (p=0.012), visits ED due falls (p<0.001), diagnosis chronic pulmonary disease (p=0.029) hematologic pathologies (p=0.047), need hospitalization (p=0.018). No associations time, drugs taken daily nor its type (anxiolytics, antiepileptics, corticoids), (and localization), overweight/obesity other cardiovascular factors, endocrinopathies, psychiatric or neurologic comorbidities. adjustment age, gender, anti-osteoporotic treatment comorbidities, main predictors (p=0.005), (p=0.040), (p=0.004) (p=0.040) (table 1). Table 1. Multivariate analyses: linear multiple regression fragility Determinants Unstandardized Coefficients B Standardized Beta 95.0% CI p-value Age -0.025 0.975 0.924 – 1.030 NS Gender 2.065 7.889 0.757 82.165 Number 0.186 1.204 0.846 1.713 Visits service -2.136 0.118 0.026 0.529 0.005 Chronic -1.326 0.266 0.075 0.940 0.040 Hematologic -4.296 0.014 0.001 0.255 0.004 Need -2.764 0.063 0.887 Anti-osteoporotic 0.157 1.170 0.227 6.017 CI: Confidence Interval; NS: non-significant; Conclusion: Certain seem be associated who needed more prone There might substantial missed opportunity intervention these patients. References: [1]Osteoporosis: assessing London: National Institute Health Care Excellence (UK); Feb. PMID: 32186835. [2]Crandall CJ, Hovey KM, Cauley JA, Andrews CA, Curtis JR, Wactawski-Wende J, Wright NC, Li W, LeBoff MS. Fracture Risk Subsequent Fracture: Findings Women’s Initiative Study. Journal bone mineral research: official journal American Society Bone Mineral Research. 2015;30(11):2086–2095. doi: 10.1002/jbmr.2559. Disclosure Interests: None declared